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What is Semaglutide?

What is Semaglutide?

Ø Semaglutide is indicated as an adjunct to a nutritionally sound balanced eating pattern and regular physical activity for chronic and/or resistant weight management in adults.

Ø Unlike other weight loss medications, you may choose to continue taking it as long as you think it is helpful on a titrated maintenance dose.

Ø During its circulation, it interacts with several organs in our body that work together to contribute to weight loss.

Semaglutide + is:

Ø Semaglutide plus Vitamin B12 and Vitamin B6 which both help with energy levels, interact with the nervous system, and help control any side effects of nausea and fatigue.


Ø We know obesity is a challenging disease to manage and involves more than just a quick fix. In fact, the quick fix never works or at least not for long. True weight management involves changes in lifestyle and a life long willingness to work those changes on a daily basis.

Ø If you would like to be referred to a Dietitian, Nutritionist, or other counseling, we encourage that and can make that referral for you.

The Nouveau Program

Ø There will be an initial assessment visit with an RN to review your Health History, Nutritional History including current food patterns and relationship with food, check Blood Sugars, collect weight, set a goal weight, and establish dose titration.

Ø Semaglutide is an injectable. We use a very small needle and the medication is injected subcutaneously, so just under the skin, and can be injected at any site on the body.

Ø The first injection will be done in the office with the RN.

Ø Week 1 – 4 you are required to come into the office for your injection to assess you for any untoward side effects. Once we have established you are tolerating the medication and feel your body is handling it in a safe and effective manner, we move on to:

Ø Week 5-8 where you will see the RN in office again at week 5, receive your dose titration and a lesson on self-administration. You will receive 3 prepared syringes for the next 3 weeks.

Ø Week 9-12: You will return to the office on Week 9 to again receive your dose titration, monitor side effects, weight loss, and a review of your new eating patterns. This pattern of review and dosage adjustment continues until you reach your goal weight.

Ø If you are uncomfortable with self-administration, you may receive all of your weekly injections in the office.

How Will I Feel?

Initially you may experience some slight nausea and tiredness. The B12 and B6 are added to help manage those symptoms. You will also not feel hungry most of the time and when you do, you will be satisfied with less food. Foods rich in sugar and fat may be more offensive to you and alcohol may also cause you to feel nausea. You will learn with the first 4 weeks what works for you and what doesn’t.

What are the possible Side Effects?

I will go through the systems and organs involved and explain the side effects related to each system at the end of this document.

Who Should Absolutely NOT Take Semaglutide

People with current thyroid cancer or a history of it or a family history of it.


Pricing is based on your dosage and as your dose is titrated up the price is titrated accordingly. The initial dose will always start at .25 mg.


.25 mg: $333 for 4 injections.

.5 mg: $444 for 4 injections

1.0 mg: $555 for 4 injections.

The dose is titrated when your weight plateaus. If you continue to progress at a safe rate of an average 2 lb/week, you will continue at that dose.

Systems Review – How Semaglutide Affects the Body

The Pancreas

Semaglutide affects Insulin production and improves the body’s cells insulin sensitivity so that more sugar is moved from the bloodstream to the cells to be used to produce energy.

The GI Tract (Gut)

Semaglutide works in the GI tract to curb hunger by slowing down gastric motility so the food stays longer in the stomach making us feel fuller longer. It also increases intestinal mucous production and decreases acid production. These changes may be the primary cause of the GI side effects that some patients may experience, including nausea, diarrhea, or constipation.

The Heart

Though semaglutide is safe for most people with cardiovascular disease, there are receptors for it in the heart. Some people may experience an increase in heart rate, so if you have a history of heart racing or irregular heart rate, it would be advisable to check with your doctor before starting semaglutide.

The Brain

The hypothalamus is the part of the brain that controls hunger and satisfaction. Semaglutide works on the hypothalamus to increase feelings of fullness and alter the food/reward system and change taste preferences so that the preference is less sugar and fat and healthier food choices.

Our Metabolism

Semaglutide appears to impact metabolism beneficially by promoting fat oxidation, meaning it preferentially breaks down stored fat for energy which in turn promotes weight loss.

The Liver

The Liver has the ability to make sugar. Semaglutide discourages the liver from making sugar, so there is less circulating hence the body burns more fat for energy rather than relying on sugar and carbohydrates.

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